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Brachytherapy is an efficient treatment for numerous cancer diseases. To support this, the Cancer News regularly inform about related studies and articles as well as cancer demographics. Subscribe to our newsletter to receive the latest news first:
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May 04, 2016

Proposal to improve commissioning of HDR brachytherapy with results from the first 2 SagiNova® units

Purpose: Commissioning of HDR brachytherapy treatment equipment is essential to avoid errors and assure quality. However, it is estimated that worldwide, less than onequarter of centres undertake robust local commissioning tests at installation [1], important checks may be omitted [2], or systematic errors may remain [3]...

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April 29, 2016

Image guided brachytherapy in locally advanced cervical cancer: Improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study

Purpose: Image guided brachytherapy (IGBT) for locally advanced cervical cancer allows dose escalation to the high-risk clinical target volume (HRCTV) while sparing organs at risk (OAR). This is the first comprehensive report on clinical outcome in a large multi-institutional cohort...

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April 27, 2016

Brachytherapy improves survival for inoperable early stage endometrial cancer

Women who have early stage endometrial cancer and are inoperable tend to live longer if they have been treated with brachytherapy with or without external beam radiation, according to new research to be presented at the 3rd ESTRO Forum in Barcelona, Spain, on Sunday...

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April 21, 2016

Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: Analysis from the retroEMBRACE study

Background and purpose: Image guided adaptive brachytherapy (IGABT) using intracavitary applicators (IC) has led to a significant improvement of local control in locally advanced cervical cancer (LACC). Further improvement has been obtained with combined intracavitary/interstitial (IC/IS) applicators. The aim of this analysis was to evaluate the impact on local control and late morbidity of application of combined IS/IC brachytherapy...

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April 08, 2016

American Brachytherapy Task Group Report: Adjuvant vaginal brachytherapy for early-stage endometrial cancer: A comprehensive review

Abstract: This article aims to review the risk stratification of endometrial cancer, treatment rationale, outcomes, treatment planning, and treatment recommendations of vaginal brachytherapy (VBT) in the postoperative management of endometrial cancer patients...

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March 22, 2016

American Brachytherapy Task Group Report: A pooled analysis of clinical outcomes for high-dose-rate brachytherapy for cervical cancer

Purpose: Advanced imaging used in combination with brachytherapy (BT) has revolutionized the treatment of patients with cervical cancer. We present a comprehensive review of the literature for definitive radiation with high-dose-rate (HDR) BT. In addition, we investigate potential outcome improvement with image-based brachytherapy (IBBT)...

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March 16, 2016

Research Network Bringing Cervical Cancer Clinical Trials to Countries Where Disease Has High Burden

The Cervix Cancer Research Network (CCRN) is working to facilitate clinical trials of treatments of cancer of the cervix in countries where the disease has a high burden and national research groups have not yet been established...

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January 11, 2016

As number of cancer survivors grows, so does rate of second malignancies

There are approximately 14.5 million cancer survivors in the United States, according to the American Cancer Society. That number is expected to climb to nearly 19 million by 2024, the society estimates. Although advances in early detection and treatment have dramatically increased the likelihood that Americans will survive their initial cancer diagnosis...
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December 15, 2015

New cancer treatment machine coming to PRMC - WMDT47 News Report

SALISBURY, Md. - Imagine treating cancer with a radiation device smaller than your fingernail all while not damaging your other organs inside your body. It's all possible with a machine called SagiNova. SagiNova is a high dose rate brachytherapy machine that is used to treat different cancers with radiation...

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December 15, 2015

Peninsula Regional Medical Center Installs Nation’s First SagiNova® High Dose Rate Afterloader System for Improved Cancer Treatment Options

Peninsula Regional Medical Center in Salisbury has become the first location in the United States to install Eckert & Ziegler BEBIG, Inc.’s new SagiNova® High Dose Rate afterloader system...
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December 09, 2015

ESMO–ESGO–ESTRO consensus conference on endometrial cancer: Diagnosis, treatment and follow-up

The first joint European Society for Medical Oncology (ESMO), European SocieTy for Radiotherapy & Oncology (ESTRO) and European Society of Gynaecological Oncology (ESGO) consensus conference on endometrial cancer was held on 11–13 December 2014 in Milan, Italy, and comprised a multidisciplinary panel of 40 leading experts in the management of endometrial cancer...
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November 24, 2015

Helping Asia Fight Cancer Through Advanced Brachytherapy

Cervical cancer patients often require a specific, technically challenging treatment that is not always readily available in developing countries. In Asia, which accounts for close to half of the world’s cervical cancer deaths, the IAEA has completed a four-year project to increase survival rates. Over 1000 specialists were trained on 3D image-guided brachytherapy, an advanced form of radiotherapy...
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October 10, 2015

Late toxicity of brachytherapy after female genital tract tumors treated during childhood: Prospective evaluation with a long-term follow-up

Purpose: To prospectively assess the long-term toxicities of brachytherapy in female survivors with localized genital tract tumors...
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July 17, 2015

Can we shorten the overall treatment time in postoperative brachytherapy of endometrial carcinoma? Comparison of two brachytherapy schedules

Purpose: To analyze vaginal-cuff relapses (VCR) and toxicity of two brachytherapy (BT) schedules in postoperative endometrial carcinoma and to correlate vaginal toxicity with vaginal-surface-EQD2Gy3 dose (VS-EQD2Gy3)...
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July 13, 2015

New Guidelines on Radiation Therapy After Surgery for Endometrial Cancer

The American Society of Clinical Oncology (ASCO) today issued an endorsement of the American Society for Radiation Oncology (ASTRO) clinical practice guideline on postoperative radiation therapy for women with endometrial (uterine) cancer. The endorsement outlines treatments that ASTRO and ASCO agree should be the standard of care for women with endometrial cancer, based on the best available evidence...
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January 09, 2015

A multicentre ‘end to end’ dosimetry audit for cervix HDR brachytherapy Treatment

Purpose: To undertake the first multicentre fully ‘end to end’ dosimetry audit for HDR cervix brachytherapy, comparing planned and delivered dose distributions around clinical treatment applicators, with review of local procedures...
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September 18, 2014

Definitive salvage for vaginal recurrence of endometrial cancer: The impact of modern intensity-modulated-radiotherapy with image-based HDR brachytherapy and the interplay of the PORTEC 1 risk stratification

Purpose: Data for salvage radiotherapy for recurrent endometrial cancer are limited especially in the era of modern radiotherapy including IMRT and 3-dimensional image-based HDR brachytherapy. Theoretically, modern radiotherapy reduces the dose to critical organs-at-risk...
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July 30, 2014

Comparison of planned and measured rectal dose in-vivo during high dose rate Cobalt-60 brachytherapy of cervical cancer

Cobalt-60 (Co-60) is a relatively new source for the application of high-dose rate (HDR) brachytherapy. Radiation dose to the rectum is often a limiting factor in achieving the full prescribed dose to the target during brachytherapy of cervical cancer. The aim of this study was to measure radiation doses to the rectum in-vivo during HDR Co-60 brachytherapy...

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June 26, 2014

MRI findings at image guided adaptive cervix cancer brachytherapy: radiation oncologist’s perspective

Magnetic resonance imaging (MRI) represents the reference imaging modality for image guided adaptive brachytherapy (IGABT) of cervix cancer. Accurate interpretation of pre-treatment MRI is required for proper understanding of the tumor extent and topography at IGABT. Planning and optimal timing of the application begins already before treatment...

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May 28, 2014

Brachytherapy in the treatment of cervical cancer: a review

Abstract: Dramatic advances have been made in brachytherapy for cervical cancer. Radiation treatment planning has evolved from two-dimensional to three-dimensional, incorporating magnetic resonance imaging and/or computed tomography into the treatment paradigm. This allows for better delineation and coverage of the tumor, as well as improved avoidance of surrounding organs...

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September 26, 2013

Vaginal cuff dehiscence after vaginal cuff brachytherapy for uterine cancer. A case report

Vaginal cuff dehiscence is a rare, but potentially serious complication after total hysterectomy. We report a case of vaginal cuff dehiscence after vaginal cuff brachytherapy. A 62 year old female underwent a robotic-assisted laparoscopic hysterectomy with bilateral salpingo-oophorectomy...

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September 26, 2013

EGSnrc Monte Carlo-aided dosimetric studies of the new BEBIG 60Co HDR brachytherapy source

Purpose: The purpose of this study is to obtain the dosimetric parameters of the new BEBIG 60Co brachytherapy source following by TG-43U1 recommendation with appropriate electron cutoff energy (0.521 MeV)...

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May 20, 2013

Trends in the Utilization of Brachytherapy in Cervical Cancer in the United States

Purpose: To determine the trends in brachytherapy use in cervical cancer in the United States and to identify factors and survival benefits associated with brachytherapy treatment...

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March 31, 2012

Treatment planning study of the 3D dosimetric differences between Co-60 and Ir-192 sources in high dose rate (HDR) brachytherapy for cervix cancer

Purpose: To evaluate whether Co-60 is equivalent to Ir-192 for HDR cervical brachytherapy, through 3D-DVH dose comparisons in standard and optimised plans. Previous studies have only considered 2D dosimetry, point dose comparisons or identical loading. Typical treatment times and economics are considered...

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January 30, 2012

Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (IV): Basic principles and parameters for MR imaging within the frame of image based adaptive cervix cancer brachytherapy

The GYN GEC-ESTRO working group issued three parts of recommendations and highlighted the pivotal role of MRI for the successful implementation of 3D image-based cervical cancer brachytherapy (BT)...

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January 19, 2012

American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part I: General principles

Purpose: To develop brachytherapy recommendations covering aspects of pretreatment evaluation, treatment, and dosimetric issues for locally advanced cervical cancer...

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January 19, 2012

American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: High-dose-rate brachytherapy

Purpose: This report presents the 2011 update to the American Brachytherapy Society (ABS) high-dose-rate (HDR) brachytherapy guidelines for locally advanced cervical cancer...

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January 19, 2012

American Brachytherapy Society consensus guidelines for interstitial brachytherapy for vaginal cancer

Purpose: To present recommendations for the use of interstitial brachytherapy in patients with vaginal cancer or recurrent endometrial cancer in the vagina...

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December 31, 2011

Comparison of 60Co and 192Ir sources in HDR brachytherapy

This paper compares the isotopes 60Co and 192Ir as radiation sources for high-dose-rate (HDR) afterloading brachytherapy. The smaller size of 192Ir sources made it the preferred radionuclide for temporary brachytherapy treatments. Recently also 60Co sources have been made available with identical geometrical dimensions...

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July 01, 2011

Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer

Background: To analyse the overall clinical outcome and benefits by applying protocol based image guided adaptive brachytherapy combined with 3D conformal external beam radiotherapy (EBRT) ± chemotherapy (ChT)... 

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June 30, 2011

A comprehensive study on HDR brachytherapy treatments of cervical cancers: using the first Co-60 BEBIG Multisource Unit in Bangladesh

Purpose: The report presents an extraordinary synthesis of customer acceptance procedures (CAP), quality assurance tests (QA) in the treatment of cervical cancer patients, using the first Co-60 Multisource Unit® in Bangladesh. The QA and commissioning required measurements and emergency tests verifying the functional limits of parameters...

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June 30, 2011

Preoperative high dose rate brachytherapy for clinical stage II endometrial carcinoma

Purpose: We sought to evaluate pathological response, tolerance, and outcome after preoperative (neoadjuvant) high dose rate brachytherapy in a small series of patients with clinical stage II endometrial carcinoma, and to evaluate a dose and fractionation protocol for this treatment...

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GEC-ESTRO Handbook of Brachytherapy:


ABS Brachytherapy Guidelines and Consensus Statements: