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December 30, 2016

Biochemical control and toxicity for favorable- and intermediate-risk patients using real-time intraoperative inverse optimization prostate seed implant: Less is more!

PURPOSE: To report the biochemical control rate and clinical outcomes with real-time inverse planning (inverse optimization prostate seed implant [IO-PSI]) for favorable-risk (FR) and intermediate-risk (IR) prostate adenocarcinoma in a community practice setting. This analysis is an extended followup of our initial report, with favorable early biochemical control rate (biochemical nonevidence of disease) of 97% at 4 years...

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December 30, 2016

Whole breast irradiation vs. APBI using multicatheter brachytherapy in early breast cancer – simulation of treatment costs based on phase 3 trial data

Purpose: A recent large phase 3 trial demonstrated that the efficacy of accelerated partial-breast irradiation (APBI) in the treatment of early breast cancer is non-inferior to that of whole breast irradiation (WBI) commonly used in this indication...

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December 30, 2016

Comparative cost-effectiveness of focal and total salvage 125I brachytherapy for recurrent prostate cancer after primary radiotherapy

Purpose: Focal salvage (FS) iodine 125 (125I) brachytherapy could be an effective treatment for locally radiorecurrent prostate cancer (PCa). Toxicity is often reduced compared to total salvage (TS) while cancer control can be maintained, which could increase cost-effectiveness...

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December 28, 2016

CT-Planned, High-Dose-Rate Brachytherapy Effective in Cervical Cancer

The use of computed-tomography (CT)-planned high-dose-rate (HDR) intracavitary brachytherapy (BT) demonstrated excellent local control (LC) and survival for patients with stage I/II cervical carcinoma, according to the results of a recent study published in Gynecologic Oncology. With a median follow-up of 30 months, no patients experienced local-only recurrence...

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December 26, 2016

CT-Guided 125I Seed Interstitial Brachytherapy as a Salvage Treatment for Recurrent Spinal Metastases after External Beam Radiotherapy

Abstract: The aim of this study is to evaluate the feasibility, safety, and clinical efficacy of CT-guided 125I seed interstitial brachytherapy in patients with recurrent spinal metastases after external beam radiotherapy (EBRT). Between August 2003 and September 2015, 26 spinal metastatic lesions (24 patients) were reirradiated by this salvage therapy modality...

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December 08, 2016

Effect of population breast screening on breast cancer mortality up to 2005 in England and Wales: an individual-level cohort study

Background:  Population breast screening has been implemented in the UK for over 25 years, but the size of benefit attributable to such programmes remains controversial. We have conducted the first individual-based cohort evaluation of population breast screening in the UK, to estimate the impact of the NHS breast screening programme (NHSBSP) on breast cancer mortality...

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November 25, 2016

ASTRO updates clinical guidance on accelerated radiation therapy for breast cancer

The American Society for Radiation Oncology (ASTRO) has updated to its Evidence-Based Consensus Statement for the use of Accelerated Partial Breast Irradiation (APBI) brachytherapy to include younger patients and those with low-risk ductal carcinoma in situ (DCIS)...

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November 24, 2016

Comorbidity as a predictor of overall survival in prostate cancer patients treated with external beam radiotherapy combined with HDR brachytherapy boosts

Background: The risk stratification currently applied prior to curative treatment for localized prostate cancer (PC) does not take into account comorbidity or age. Therefore, we investigated the impact of comorbidity on overall survival (OS) in PC patients treated with external beam radiotherapy (EBRT) and high-dose rate (HDR) brachytherapy boost...

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October 31, 2016

Cervical cancer brachytherapy in Canada: A focus on interstitial brachytherapy utilization

PURPOSE: Brachytherapy (BT) techniques for cervical cancer in Canada have changed over the last decade, with evolution to high-dose-rate and image-guided BT. However, there are currently no national data on the use of interstitial BT (IBT). The purpose of this study was to document IBT utilization in Canadian centers, as well as update details of cervical cancer BT practices...

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October 21, 2016

American Brachytherapy Society: Brachytherapy treatment recommendations for locally advanced cervix cancer for low-income and middle-income countries

Purpose: Most cervix cancer cases occur in low-income and middle-income countries (LMIC), and outcomes are suboptimal, even for early stage disease. Brachytherapy plays a central role in the treatment paradigm, improving both local control and overall survival. The American Brachytherapy Society (ABS) aims to provide guidelines for brachytherapy delivery in resource-limited settings...

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October 19, 2016

American Brachytherapy Society Task Group Report: Combination of brachytherapy and external beam radiation for high-risk prostate cancer

Purpose: To review outcomes for high-risk prostate cancer treated with combined modality radiation therapy (CMRT) utilizing external beam radiation therapy (EBRT) with a brachytherapy boost...

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October 11, 2016

Prostate brachytherapy in Ghana: our initial experience

Purpose: This study presents the experience of a brachytherapy team in Ghana with a focus on technology transfer and outcome. The team was initially proctored by experienced physicians from Europe and South Africa...

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September 28, 2016

Differences in outcome for cervical cancer patients treated with or without brachytherapy

Purpose: To compare the clinical outcome of cervical cancer patients treated with primary radiotherapy with and without the addition of brachytherapy...

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September 28, 2016

Roughly half of radiotherapy candidates in developing countries lack access: ASTRO

The topic was the roadblocks preventing access to radiation therapy treatment in developing countries, and the message was simple: shipping capital equipment to these regions is not enough... 

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September 26, 2016

ASTRO 2016: Intermediate risk prostate cancer may be well controlled with brachytherapy alone

For men with intermediate risk prostate cancer, radiation treatment with brachytherapy alone can result in similar cancer control with fewer long-term side effects, when compared to more aggressive treatment that combines brachytherapy with external beam therapy (EBT)...

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August 19, 2016

PSA Testing Advocates Earn Win with Medicare

For many of the thousands of American men who will be diagnosed with prostate cancer this year, the prostate-specific antigen test is the tool that will set off early alarm bells in their cases. This test, heavily under fire in recent years, just won a victory that advocates have been hoping for...

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August 18, 2016

Pattern of Breast Cancer Distribution in Ghana: A Survey to Enhance Early Detection, Diagnosis, and Treatment

Background: Nearly 70% of women diagnosed with breast cancer in Ghana are in advanced stages of the disease due especially to low awareness, resulting in limited treatment success and high death rate. With limited epidemiological studies on breast cancer in Ghana, the aim of this study is to assess and understand the pattern of breast cancer distribution for enhancing early detection and treatment...

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August 10, 2016

Receipt of Vaginal Brachytherapy Is Associated With Improved Survival in Women With Stage I Endometrioid Adenocarcinoma of the Uterus: A National Cancer Data Base Study

BACKGROUND: Randomized controlled trials have consistently shown that the use of postoperative radiotherapy (RT) for stage I endometrial cancer leads to a reduction in the incidence of pelvic recurrences without a corresponding reduction in overall mortality...

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July 31, 2016

For very high-risk patients, EBRT + BT is superior to surgery or EBRT only

A retrospective analysis of oncological outcomes among modern-era patients with a Gleason score of 9 or 10 demonstrates a clear advantage to a combination of external beam radiation therapy (EBRT) with a brachytherapy (BT) boost to the prostate and short–term androgen deprivation therapy (ADT)...

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July 01, 2016

American Brachytherapy Society Task Group Report: Combined external beam irradiation and interstitial brachytherapy for base of tongue tumors and other head and neck sites in the era of new technologies

Abstract: Irradiation plays an important role in the treatment of cancers of the head and neck providing a high locoregional tumor control and preservation of organ functions. External beam irradiation (EBI) results in unnecessary radiation exposure of the surrounding normal tissues increasing the incidence of side effects (xerostomy, osteoradionecrosis, and so forth)...

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June 29, 2016

Modelling second malignancy risks from low dose rate and high dose rate brachytherapy as monotherapy for localised prostate cancer

Background and purpose: To estimate the risks of radiation-induced rectal and bladder cancers following low dose rate (LDR) and high dose rate (HDR) brachytherapy as monotherapy for localised prostate cancer and compare to external beam radiotherapy techniques...

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June 27, 2016

Commissioning and Quality Control of the New Saginova HDR Treatment System; First Year Experience from the United Kingdom and Germany

Purpose: It is estimated that worldwide, less than one-quarter of centres undertake their own comprehensive local commissioning tests at installation of new HDR Brachytherapy equipment [1]. Commissioning and routine quality control (QC) of HDR brachytherapy treatment equipment is essential to avoid errors and assure quality...

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June 19, 2016

High Dose Rate Brachytherapy as a Treatment Option in Endobronchial Tumors

Purpose: To report our experience with high dose rate endobronchial brachytherapy (HDR-EBBT) and to assess its efficacy and tolerability with possibility of its use in selected cases with curative intent...

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June 16, 2016

Long-term results of permanent implant prostate cancer brachytherapy: A single-institution study of 675 patients treated between 1999 and 2003

Purpose: To analyse long-term overall survival, relapse-free survival and late toxicities in a series of 675 patients treated between 1999 and 2003, with a median follow-up of 132 months...

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June 15, 2016

The American College of Radiology and the American Brachytherapy Society practice parameter for the performance of low-dose-rate brachytherapy

Abstract: Brachytherapy is the use of radionuclides to treat malignancies or benign conditions by means of a radiation source placed close to or into the tumor or treatment site. This practice parameter refers only to the use of radionuclide brachytherapy. Brachytherapy alone or combined with external beam therapy plays an important role in the management and treatment of patients with cancer...

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June 01, 2016

Robustness to source displacement in dual air kerma strength planning for focal low-dose-rate brachytherapy of prostate cancer

Purpose: To describe the use of dual source strength implants for focal low-dose-rate brachytherapy...
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June 01, 2016

Guidelines by the AAPM and GEC-ESTRO on the use of innovative brachytherapy devices and applications: Report of Task Group 167

Although a multicenter, Phase III, prospective, randomized trial is the gold standard for evidence-based medicine, it is rarely used in the evaluation of innovative devices because of many practical and ethical reasons. It is usually sufficient to compare the dose distributions and dose rates for determining the equivalence of the innovative treatment modality to an existing one...

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May 31, 2016

Adjuvant vaginal brachytherapy for early-stage endometrial cancer: A comprehensive review

This article aims to review the risk stratification of endometrial cancer, treatment rationale, outcomes, treatment planning, and treatment recommendations of vaginal brachytherapy (VBT) in the postoperative management of endometrial cancer patients...

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May 27, 2016

Improved 10 Year Outcome for Prostate Cancer Patients Receiving High-Dose-Rate (HDR) Brachytherapy Boost to External Beam Radiotherapy (EBRT) Compared with EBRT Alone

Purpose: HDR brachytherapy boost is utilized for dose escalation in the treatment of clinically localized intermediate to high risk prostate cancer, but long term clinical outcome data continues to mature...

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May 16, 2016

Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound Fusion

Prostate cancer is the most common malignancy found in North American and European men and the second most common cause of cancer related death. Since the practice of PSA screening has become common the disease is most often found early and can have a long indolent course...

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May 13, 2016

Low-dose rate brachytherapy with I-125 seeds has an excellent 5-year outcome with few side effects in patients with low-risk prostate cancer

BACKGROUND: Low-dose rate brachytherapy (LDR-BT) has been used in Sweden for more than a decade for treatment of low-risk prostate cancer. This study presents the outcome for patients treated with LDR-BT at a single institution with focus on the association between dose and biochemical failure-free survival (BFFS)...

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May 08, 2016

Higher Radiation Dose Key to Better Brachytherapy Outcomes

Higher radiation doses are critical to optimizing long-term outcomes following brachytherapy for prostate cancer (PCa), a study presented at the American Urological Association 2016 annual meeting suggests...

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May 07, 2016

Erectile Function Preserved in Half of Men Receiving Brachytherapy

Potency is preserved in half of men a decade after prostate brachytherapy, researchers revealed at the 2016 American Urological Association meeting. Pre-treatment erectile function (EF), patient age, and use of neoadjuvant hormone therapy (NHT) appeared to influence long-term EF after radioactive seed implantation...

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May 05, 2016

Reevaluating PSA Testing Rates in the PLCO Trial

In March, the Centers for Medicare and Medicaid Services temporarily suspended the development of a proposed “Non-Recommended Prostate-Specific Antigen (PSA)–Based Screening” measure that would discourage PSA screening in all men...

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May 04, 2016

Proposal to improve commissioning of HDR brachytherapy with results from the first 2 SagiNova® units

Purpose: Commissioning of HDR brachytherapy treatment equipment is essential to avoid errors and assure quality. However, it is estimated that worldwide, less than onequarter of centres undertake robust local commissioning tests at installation [1], important checks may be omitted [2], or systematic errors may remain [3]...

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May 03, 2016

ESTRO 2016: Accelerated Partial Breast Irradiation (APBI) with multicatheter interstitial brachytherapy shows positive cosmesis and favorable late side effects

Clinical equivalence of partial breast irradiation (PBI) and whole breast irradiation (WBI) has been demonstrated in two key phase III randomised trials: the Groupe Européen de Curiethérapie European Society for Therapeutic Radiology and Oncology (GEC-ESTRO)...

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April 29, 2016

Image guided brachytherapy in locally advanced cervical cancer: Improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study

Purpose: Image guided brachytherapy (IGBT) for locally advanced cervical cancer allows dose escalation to the high-risk clinical target volume (HRCTV) while sparing organs at risk (OAR). This is the first comprehensive report on clinical outcome in a large multi-institutional cohort...

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April 27, 2016

Brachytherapy improves survival for inoperable early stage endometrial cancer

Women who have early stage endometrial cancer and are inoperable tend to live longer if they have been treated with brachytherapy with or without external beam radiation, according to new research to be presented at the 3rd ESTRO Forum in Barcelona, Spain, on Sunday...

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April 22, 2016

High-dose-rate interstitial brachytherapy as monotherapy in one fraction for the treatment of favorable stage prostate cancer: Toxicity and long-term biochemical results

Background: To evaluate acute and late genitourinary, the gastrointestinal toxicity and the long-term biochemical control after HDR monotherapy in one fraction (19 Gy)...

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April 21, 2016

Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: Analysis from the retroEMBRACE study

Background and purpose: Image guided adaptive brachytherapy (IGABT) using intracavitary applicators (IC) has led to a significant improvement of local control in locally advanced cervical cancer (LACC). Further improvement has been obtained with combined intracavitary/interstitial (IC/IS) applicators. The aim of this analysis was to evaluate the impact on local control and late morbidity of application of combined IS/IC brachytherapy...

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April 18, 2016

Demand for radiotherapy will rise substantially over next ten years; planning to deal with increase in new cancer cases should start now

The demand for radiotherapy across all European countries will increase by an average of 16% between 2012 and 2025, with the highest expected increase being for prostate cancer cases (24%), according to a new study published in Radiotherapy and Oncology [1]...

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April 18, 2016

Making Radiation Therapy for Prostate Cancer More Economical and More Convenient

Why is radiation therapy not simply given in one large dose? This is a question that patients often ask of their radiation oncologists. The answer is simple: it could be, but such a dose would be equally damaging to the cancer and to the normal tissues within the radiation field...

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April 13, 2016

An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis

Background: Prostate cancer (PCa) is rated the second most common cancer and sixth leading cause of cancer deaths among men globally. Reports show that African men suffer disproportionately from PCa compared to men from other parts of the world...

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April 08, 2016

American Brachytherapy Task Group Report: Adjuvant vaginal brachytherapy for early-stage endometrial cancer: A comprehensive review

Abstract: This article aims to review the risk stratification of endometrial cancer, treatment rationale, outcomes, treatment planning, and treatment recommendations of vaginal brachytherapy (VBT) in the postoperative management of endometrial cancer patients...

Read More


April 06, 2016

Is there an optimal treatment schedule for high-dose-rate brachytherapy?

Protocols for high-dose-rate brachytherapy (HDR-BT) monotherapy vary. In recent years, practitioners have adopted various schedules for patient and physician convenience. Jawad et al. reported on the HDR-BT experience at William Beaumont Hospital. They treated 494 favorable-risk patients using three different treatment schedules...
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April 01, 2016

Efficacy and Feasibility of Low-Dose Rate Brachytherapy for Prostate Cancer in Renal Transplant Recipients

BACKGROUND: In young patients with localized prostate cancer, radical prostatectomy is the treatment of choice in the general population. Radiotherapy, such as low-dose rate (LDR) brachytherapy or intensity-modulated radiotherapy, is a viable alternative as well. However, in transplant patients, irradiation is...

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March 22, 2016

American Brachytherapy Task Group Report: A pooled analysis of clinical outcomes for high-dose-rate brachytherapy for cervical cancer

Purpose: Advanced imaging used in combination with brachytherapy (BT) has revolutionized the treatment of patients with cervical cancer. We present a comprehensive review of the literature for definitive radiation with high-dose-rate (HDR) BT. In addition, we investigate potential outcome improvement with image-based brachytherapy (IBBT)...

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March 16, 2016

Hospital volume tied to success of radiation therapy for prostate cancer

Men with aggressive prostate cancer are more likely to survive if they receive radiation therapy at a hospital that provides the treatment to a large number of patients, researchers report...

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March 16, 2016

Research Network Bringing Cervical Cancer Clinical Trials to Countries Where Disease Has High Burden

The Cervix Cancer Research Network (CCRN) is working to facilitate clinical trials of treatments of cancer of the cervix in countries where the disease has a high burden and national research groups have not yet been established...

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March 09, 2016

Analysis of Secondary Primary Tumors In Patients With Uveal Melanoma

Uveal melanoma (UM) is the most common malignant tumor of the eye in adults. More than half of the patients are long-term survivors. It is well established for other malignancies that cancer survivors are especially prone to developing independent second primary neoplasms...

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