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Cancer News Around the Web

July 05, 2019

Accelerated partial-breast irradiation with high-dose-rate brachytherapy: Mature results of a Phase II trial

Purpose: The purpose of this study was to report mature clinical and cosmetic results of accelerated partial-breast irradiation with interstitial multicatheter high-dose-rate brachytherapy (HDR-BRT) in patients with early breast cancer...

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July 01, 2019

125I low-dose-rate prostate brachytherapy and radical prostatectomy in patients with prostate cancer

Radical prostatectomy (RP) and low-dose-rate prostate brachytherapy (LDR) are two widely used treatment options for patients with T1c-T3a prostate cancer. In the present study, the efficacy of the two treatments was compared...

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June 18, 2019

Prospective four years of evaluation of erectile function after low-dose-rate prostate brachytherapy using baseline IIEF-5 > 16

Purpose: Prostate cancer (CaP) is the second most common cancer and the fifth leading cause of death from cancer in men in the world [1]. Nowadays, many treatment options available are responsible for side effects, mainly urinary and sexual...

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June 18, 2019

Long-term efficacy and urological toxicity of low-dose-rate brachytherapy (LDR-BT) as monotherapy in localized prostate cancer

Purpose: The purpose of this study was to evaluate the incidence of late severe (≥Grade 3) urinary toxicity and the long-term efficacy after low-dose-rate brachytherapy (LDR-BT) in patients with localized prostate cancer (PCa)...

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June 11, 2019

Vaginal brachytherapy alone for patients with Stage II endometrial cancer with inner half cervical stromal invasion

Purpose: The purpose of this study was to review outcomes of women with Stage II endometrial carcinoma with inner half cervical stromal invasion treated with adjuvant vaginal brachytherapy (VB) alone...

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June 10, 2019

Effectiveness of Image-guided Brachytherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Receiving Concurrent Chemoradiotherapy

Aim: To compare the advantage of image-guided brachytherapy (IGBT) over conventional two-dimensional brachytherapy (2DBT) in patients with advanced cervical squamous cell carcinoma...

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June 10, 2019

Influence of dwell time homogeneity error weight parameter on treatment plan quality in inverse optimized HDR cervix brachytherapy using SagiPlan

Purpose: Over the past decade, high-dose-rate (HDR) cervix brachytherapy has benefited from more widespread use of 3D image-based treatment planning techniques, completed mainly with the use of computed tomography (CT) and/or magnetic resonance imaging (MRI). A shift from applicator-based optimization methods to anatomy-based inverse optimization has resulted from these developments [1,2,3,4]...

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June 03, 2019

Cosmetic assessment in brachytherapy (interventional radiotherapy) for breast cancer: A multidisciplinary review

Purpose: This review was to focus on breast brachytherapy cosmetic assessment methods state of the art and to define the advantages and disadvantages related to...

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May 29, 2019

Biochemical outcomes and predictive factors by risk group after permanent iodine-125 seed implantation: Prospective cohort study in 2,316 patients

Purpose: To evaluate the biochemical freedom from failure (bFFF) by risk group and treatment modality and the predictive factors of bFFF by risk group in patients with prostate cancer undergoing permanent seed implantation (PI) with or without external beam radiation therapy (EBRT) in a nationwide prospective cohort study (Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 [I-125] Seed Implantation)...

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May 06, 2019

Role of novel imaging in the management of prostate cancer

This review summarizes novel imaging in the management of prostate cancer including multiparametric MRI, PET-CT scans with different radiotracers including 11C-acetate, 11C-choline, 18F-choline, 18F sodium fluoride, prostate-specific membrane antigen, and anti-1-amino-3-[18F] fluorocyclobutane-1-carboxylic acid (fluciclovine)...

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May 03, 2019

The current state of randomized clinical trial evidence for prostate brachytherapy

Interstitial brachytherapy is one of several curative therapeutic options for the treatment of localized prostate cancer. In this review, we summarize all available randomized data to support the optimal use of prostate brachytherapy...

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May 02, 2019

‘Fake News’ in urology: evaluating the accuracy of articles shared on social media in genitourinary malignancies

Objectives: To evaluate the accuracy of the most popular articles on social media platforms pertaining to genitourinary malignancies, and to identify the prevalence of misinformation available to patients...

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April 29, 2019

Impact of different dose prescription schedules on EQD2 in high-dose-rate intracavitary brachytherapy of carcinoma cervix

Purpose: To observe the effect of different high-dose-rate (HDR) intracavitary brachytherapy dose schedules on equieffective dose in 2 Gy per fraction (EQD2)...

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April 29, 2019

Second breast-conserving therapy with interstitial brachytherapy (APBI) as a salvage treatment in ipsilateral breast tumor recurrence: a retrospective study of 40 patients

Purpose: Breast-conserving treatment (BCT) have emerged as an alternative to mastectomy in patients with ipsilateral breast tumor recurrence (IBTR). We evaluated survival outcomes and treatment-related toxicity in a series of 40 patients with IBTR, who underwent tumorectomy plus interstitial brachytherapy (APBI) as a salvage treatment...

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April 09, 2019

Compendium of fractionation choices for gynecologic HDR brachytherapy - An American Brachytherapy Society Task Group Report

Purpose: The purpose of this study was to report a list of accepted fractionation schemes for high-dose-rate (HDR) brachytherapy for gynecological cancers in a definitive, neoadjuvant, or adjuvant setting...

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April 03, 2019

Single-fraction brachytherapy as monotherapy for early-stage prostate cancer: The UCSF experience

Purpose: High-dose-rate (HDR) brachytherapy as monotherapy is an effective treatment option for localized prostate cancer, but experience with single-fraction brachytherapy is limited by studies with small sample size. We report a large single-institution experience with single-fraction HDR brachytherapy as monotherapy for early-stage prostate cancer...

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March 16, 2019

Permanent prostate brachytherapy is safe in men with severe baseline lower urinary tract symptoms

Purpose: To evaluate the long-term urinary outcomes of men with severe pretreatment lower urinary tract symptoms (LUTS) treated with permanent prostate brachytherapy (PPB) ± external beam radiation therapy for localized prostate cancer...

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March 16, 2019

Second breast-conserving surgery and interstitial brachytherapy vs. salvage mastectomy for the treatment of local recurrences: 5-year results

Purpose: The purpose of this study was to report the clinical outcomes of a second breast-conserving therapy (2nd BCT) with perioperative interstitial brachytherapy (iBT) vs. those of salvage mastectomy (sMT) in the treatment of ipsilateral breast tumor recurrences (IBTRs)...

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March 07, 2019

Reducing seed migration to near zero with stranded-seed implants: Comparison of seed migration rates to the chest in 1000 permanent prostate brachytherapy patients undergoing implants with loose or stranded seeds

Purpose: Pulmonary seed emboli to the chest may occur after permanent prostate brachytherapy (PPB). The purpose of this study is to analyze factors associated with seed migration to the chest in a large series of PPB patients from a single institution undergoing implant with either loose seeds (LS), mixed loose and stranded seeds (MS), or exclusively stranded seeds in an absorbable vicryl suture (VS)...

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March 05, 2019

Intraoperative brachytherapy for resected brain metastases

Brain metastases, the most common intracranial neoplasms in adults (1), develop in approximately 30% of all cancer patients, and is the cause of death in up to 50% of these individuals (2). They are commonly located at the gray–white matter interface where the blood vessel caliber decreases, and their dissemination corresponds with blood flow...

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February 28, 2019

Current state of interventional radiotherapy (brachytherapy) education in Italy: results of the INTERACTS survey

Purpose: Rapid evolution and improvement of technology in radiation oncology and the complexity of each area of radiotherapy (RT) practice determined the need for an adequate and flexible practical training system. In the field of interventional radiotherapy (brachytherapy – BT), a decline in BT utilization was detected in the 1990’s, essentially due to technological improvement of external beam RT...

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February 13, 2019

Personalized re-treatment strategy for uveal melanoma local recurrences after interventional radiotherapy (brachytherapy): single institution experience and systematic literature review

Purpose: Episcleral plaque radiotherapy is an effective method of controlling uveal melanoma locally as confirmed by long-term results [1]. Unfortunately, failure of the radioactive plaque to control tumor growth is occasionally observed [2]. Data published in a review by Chang presents local failure rates following various forms of conservative treatments for uveal melanoma [3]...

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February 07, 2019

Factors associated with deformation accuracy and modes of failure for MRI-optimized cervical brachytherapy using deformable image registration

Purpose: To identify factors associated with MRI-to-CT image deformation accuracy and modes of failure for MRI-optimized intracavitary high-dose-rate treatment of locally advanced cervical cancer...

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February 02, 2019

Understanding the underutilization of cervical brachytherapy for locally advanced cervical cancer

Purpose: To understand the reasons behind current low utilization of brachytherapy for locally advanced cervical cancer in the United States...

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February 01, 2019

Combined-modality 125J-seed-brachytherapy, external beam radiation and androgen deprivation therapy of unfavorable-risk prostate cancer: report of outcomes and side-effects

Purpose: To analyze outcomes and complication rates in an unselected cohort of men with unfavorable (NCCN intermediate and high-risk) PCa receiving combined-modality radiation treatment (CRT)...

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January 18, 2019

Brachytherapy: A critical component of primary radiation therapy for cervical cancer

Brachytherapy is well-established as an integral component in the standard of care for treatment of patients receiving primary radiotherapy for cervical cancer. A decline in brachytherapy has been associated with negative impacts on survival in the era of modern EBRT techniques...

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January 16, 2019

Impact of a dominant intraprostatic lesion (DIL) boost defined by sextant biopsy in permanent I-125 prostate implants on biochemical disease free survival (bDFS) and toxicity outcomes

Background and purpose: To compare bDFS and toxicity outcomes in a population of intermediate risk prostate cancer patients treated using I-125 LDR brachytherapy with or without DIL boost based on multiple core biopsy maps...

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January 10, 2019

Surgery Versus Radiation for High-risk Prostate Cancer: The Fight Continues. But Is It Time To Call a Draw and Reach Consensus?

Management of high-risk prostate cancer (PC) is one of the most contentious issues that urologists face. Level 1 evidence shows that adding external beam radiotherapy (EBRT) to androgen deprivation therapy (ADT) improves survival outcomes in high-risk and locally advanced PC [1]...

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January 09, 2019

Long-term oncological and functional outcomes support use of low-dose-rate brachytherapy with or without external beam radiation in young men (≤60 years) with localized prostate cancer

PURPOSE: To evaluate the oncological and functional outcomes of young men treated with low-dose-rate brachytherapy (BT) for prostate cancer (PCa)...

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January 09, 2019

A comparative analysis of overall survival between high-dose-rate and low-dose-rate brachytherapy boosts for unfavorable-risk prostate cancer

Purpose: External beam radiation therapy (EBRT) with low-dose-rate (LDR) brachytherapy boost has been associated with improved biochemical progression–free survival and overall survival (OS) compared with dose-escalated EBRT (DE-EBRT) alone for unfavorable-risk prostate cancer...

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