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Brachytherapy is an efficient treatment for numerous cancer diseases. To support this, the Cancer News regularly inform about related studies and articles as well as cancer demographics. Subscribe to our newsletter to receive the latest news first:
 
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November 11, 2019

Progress in Low Dose Rate Brachytherapy for Prostate Cancer

Low dose rate (LDR) brachytherapy has a proven critical role in achieving the modern standard of successful prostate cancer treatment, cure with quality of life (QoL) preservation. In the past decade, cure has been demonstrated in the most lethal form of prostate cancer treated with combined external beam and LDR brachytherapy...

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November 07, 2019

Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high‐risk localized prostate cancer

Background: It remains controversial if radical prostatectomy or definitive radiation therapy produces equivalent outcomes in high‐risk localized prostate cancer...

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November 05, 2019

Ten-Year Treatment Outcomes of Radical Prostatectomy vs External Beam Radiation Therapy vs Brachytherapy for 1,503 Patients with Intermediate Risk Prostate Cancer

Purpose: To compare 10-year oncologic treatment outcomes of radical prostatectomy (RP) vs external beam radiation therapy (EBRT) vs brachytherapy (BT) for patients with intermediate risk prostate cancer (IRPC)...

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October 30, 2019

Single fraction high-dose-rate brachytherapy as monotherapy for low and intermediate risk prostate cancer: toxicities and early outcomes from a single institutional experience

Purpose: High-dose-rate brachytherapy (HDR-BT) delivered in a single fraction as monotherapy is a potential treatment modality for low- and intermediate-risk prostate cancer...

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October 30, 2019

Evaluation of deformable image registration algorithm for determination of accumulated dose for brachytherapy of cervical cancer patients

Purpose: This study was designed to assess the dose accumulation (DA) of bladder and rectum between brachytherapy fractions using hybrid-based deformable image registration (DIR) and compare it with the simple summation (SS) approach of GEC-ESTRO in cervical cancer patients...

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October 30, 2019

Inter-institutional comparison of treatment practice for cervical cancer with special emphasis on brachytherapy

Purpose: To compare the cervical cancer treatment outcome and toxicities between two different institutions...

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October 30, 2019

Results from chemoradiotherapy for squamous cell cervical cancer with or without intracavitary brachytherapy

Purpose: The aim of this study is to compare the outcomes of intracavitary high-dose-rate brachytherapy (BT-IC) boost and external beam radiotherapy (EBRT) boost in patients treated with concomitant chemoradiotherapy for squamous cell carcinoma of the cervix...

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October 16, 2019

Comparison of outcome endpoints in intermediate- and high-risk prostate cancer after combined-modality radiotherapy

Purpose: To compare a standard radio-oncological and a surgical biochemical failure definition after combined-modality radiation therapy (CRT) in men with intermediate- and high-risk prostate cancer...

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September 05, 2019

Discrepancy between Expectations and Experiences after Prostate Cancer Treatment: A Dutch Multicenter Study

Objectives: To evaluate possible discrepancies between patients’ expectations concerning sexual side effects related to prostate cancer (PCa) treatment, based on the obtained information prior to treatment...

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August 29, 2019

Complications and adverse events of plaque brachytherapy for ocular melanoma

Purpose: In 2016, an estimated 2,810 new cases of primary intraocular tumors were diagnosed, having led to 280 deaths nationwide [1]. The most common primary intraocular tumor is uveal melanoma, also known as ocular melanoma...

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August 21, 2019

Receipt of brachytherapy is an independent predictor of survival in glioblastoma in the Surveillance, Epidemiology, and End Results database

There has been a resurgence of interest in brachytherapy as a treatment for glioblastoma, with several currently ongoing clinical trials. To provide a foundation for the analysis of these trials, we analyze the Surveillance, Epidemiology, and End Results (SEER)...

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August 19, 2019

How might financial pressures have impacted brachytherapy? A proposed narrative to explain the declines in cervical and prostate brachytherapy utilization

Rates of brachytherapy administration in the United States have declined for both cervical and prostate cancers, and we argue that the available facts suggest financial considerations are a major contributor to this issue...

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July 30, 2019

Brachytherapy: An overview for clinicians

Brachytherapy is a specific form of radiotherapy consisting of the precise placement of radioactive sources directly into or next to the tumor. This technique is indicated for patients affected by various types of cancers...

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July 05, 2019

Accelerated partial-breast irradiation with high-dose-rate brachytherapy: Mature results of a Phase II trial

Purpose: The purpose of this study was to report mature clinical and cosmetic results of accelerated partial-breast irradiation with interstitial multicatheter high-dose-rate brachytherapy (HDR-BRT) in patients with early breast cancer...

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July 01, 2019

125I low-dose-rate prostate brachytherapy and radical prostatectomy in patients with prostate cancer

Radical prostatectomy (RP) and low-dose-rate prostate brachytherapy (LDR) are two widely used treatment options for patients with T1c-T3a prostate cancer. In the present study, the efficacy of the two treatments was compared...

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June 18, 2019

Prospective four years of evaluation of erectile function after low-dose-rate prostate brachytherapy using baseline IIEF-5 > 16

Purpose: Prostate cancer (CaP) is the second most common cancer and the fifth leading cause of death from cancer in men in the world [1]. Nowadays, many treatment options available are responsible for side effects, mainly urinary and sexual...

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June 18, 2019

Long-term efficacy and urological toxicity of low-dose-rate brachytherapy (LDR-BT) as monotherapy in localized prostate cancer

Purpose: The purpose of this study was to evaluate the incidence of late severe (≥Grade 3) urinary toxicity and the long-term efficacy after low-dose-rate brachytherapy (LDR-BT) in patients with localized prostate cancer (PCa)...

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June 13, 2019

Long-Term Outcome of I-125 Seeds Therapy for High-Risk Prostate Cancer Patients: A Propensity Score-Matched Analysis

Purpose: The aims of this study is to report long-term outcome of patients treated with I125 low-dose-rate brachytherapy (LDR-BT) for high-risk prostate cancer with a minimum five years follow-up after the LDR-BT using a propensity score-matched analysis...

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June 13, 2019

Survival Outcomes and Toxicity of Brachytherapy (BT) versus External Beam (EBRT) Boost in the Treatment of Localized Prostate Cancer: A Systematic Review and Meta-Analysis

Purpose: High radiation doses may be delivered to the prostate with EBRT or BT. Both low (LDR)- and high dose-rate (HDR) BT have been used as means of dose escalation in randomized controlled trials (RCTs) comparing EBRT to BT boost...

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June 13, 2019

10 Year Follow-Up of a Large, Single Institution Prospective Low Dose Rate Prostate Cancer Brachytherapy Series: The Chicago Experience

Purpose: Beginning in 1997, a dedicated prostate brachytherapy center initiated a prospective data collection intended to evaluate outcomes following low dose rate brachytherapy. The goal of this report is to estimate 10-year biochemical outcomes in a large, closely followed prospective series...

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June 13, 2019

Outcomes and Toxicity Following Salvage Low-Dose-Rate Brachytherapy for Recurrent Prostate Cancer after Radiation Therapy

Purpose: Salvage low-dose-rate (LDR) brachytherapy is a viable treatment option for patients with locally recurrent prostate cancer following primary radiation therapy. Here we report our single institution experience outcomes and toxicity when utilizing LDR in the salvage brachytherapy...

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June 13, 2019

Quality of Life after Prostate Cancer Treatment Comparison between Robot Assisted Radical Prostatectomy and Brachytherapy

Purpose: Health-related quality of life (HRQOL) after the treatment must be one of the most important factor for the prostate cancer (PCa) patients for deciding treatment options. Objective of this study is to compare HRQOL of patients who underwent mono treatment of permanent seed implant brachytherapy...

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June 13, 2019

Long-Term Oncologic Outcomes of Low Dose Rate Brachytherapy Compared to Hypofractionated External Beam Radiotherapy for Intermediate Risk Prostate Cancer

Purpose: Low dose-rate brachytherapy (LDR) and hypofractionated external beam radiotherapy (EBRT) are accepted standard treatments in the setting of intermediate-risk (IR) prostate cancer...

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June 11, 2019

Vaginal brachytherapy alone for patients with Stage II endometrial cancer with inner half cervical stromal invasion

Purpose: The purpose of this study was to review outcomes of women with Stage II endometrial carcinoma with inner half cervical stromal invasion treated with adjuvant vaginal brachytherapy (VB) alone...

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June 10, 2019

Effectiveness of Image-guided Brachytherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Receiving Concurrent Chemoradiotherapy

Aim: To compare the advantage of image-guided brachytherapy (IGBT) over conventional two-dimensional brachytherapy (2DBT) in patients with advanced cervical squamous cell carcinoma...

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June 10, 2019

Influence of dwell time homogeneity error weight parameter on treatment plan quality in inverse optimized HDR cervix brachytherapy using SagiPlan

Purpose: Over the past decade, high-dose-rate (HDR) cervix brachytherapy has benefited from more widespread use of 3D image-based treatment planning techniques, completed mainly with the use of computed tomography (CT) and/or magnetic resonance imaging (MRI). A shift from applicator-based optimization methods to anatomy-based inverse optimization has resulted from these developments [1,2,3,4]...

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June 03, 2019

Cosmetic assessment in brachytherapy (interventional radiotherapy) for breast cancer: A multidisciplinary review

Purpose: This review was to focus on breast brachytherapy cosmetic assessment methods state of the art and to define the advantages and disadvantages related to...

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May 29, 2019

Biochemical outcomes and predictive factors by risk group after permanent iodine-125 seed implantation: Prospective cohort study in 2,316 patients

Purpose: To evaluate the biochemical freedom from failure (bFFF) by risk group and treatment modality and the predictive factors of bFFF by risk group in patients with prostate cancer undergoing permanent seed implantation (PI) with or without external beam radiation therapy (EBRT) in a nationwide prospective cohort study (Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 [I-125] Seed Implantation)...

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May 06, 2019

Role of novel imaging in the management of prostate cancer

This review summarizes novel imaging in the management of prostate cancer including multiparametric MRI, PET-CT scans with different radiotracers including 11C-acetate, 11C-choline, 18F-choline, 18F sodium fluoride, prostate-specific membrane antigen, and anti-1-amino-3-[18F] fluorocyclobutane-1-carboxylic acid (fluciclovine)...

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May 03, 2019

The current state of randomized clinical trial evidence for prostate brachytherapy

Interstitial brachytherapy is one of several curative therapeutic options for the treatment of localized prostate cancer. In this review, we summarize all available randomized data to support the optimal use of prostate brachytherapy...

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May 02, 2019

‘Fake News’ in urology: evaluating the accuracy of articles shared on social media in genitourinary malignancies

Objectives: To evaluate the accuracy of the most popular articles on social media platforms pertaining to genitourinary malignancies, and to identify the prevalence of misinformation available to patients...

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April 29, 2019

Impact of different dose prescription schedules on EQD2 in high-dose-rate intracavitary brachytherapy of carcinoma cervix

Purpose: To observe the effect of different high-dose-rate (HDR) intracavitary brachytherapy dose schedules on equieffective dose in 2 Gy per fraction (EQD2)...

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April 29, 2019

Second breast-conserving therapy with interstitial brachytherapy (APBI) as a salvage treatment in ipsilateral breast tumor recurrence: a retrospective study of 40 patients

Purpose: Breast-conserving treatment (BCT) have emerged as an alternative to mastectomy in patients with ipsilateral breast tumor recurrence (IBTR). We evaluated survival outcomes and treatment-related toxicity in a series of 40 patients with IBTR, who underwent tumorectomy plus interstitial brachytherapy (APBI) as a salvage treatment...

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April 09, 2019

Compendium of fractionation choices for gynecologic HDR brachytherapy - An American Brachytherapy Society Task Group Report

Purpose: The purpose of this study was to report a list of accepted fractionation schemes for high-dose-rate (HDR) brachytherapy for gynecological cancers in a definitive, neoadjuvant, or adjuvant setting...

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April 03, 2019

Single-fraction brachytherapy as monotherapy for early-stage prostate cancer: The UCSF experience

Purpose: High-dose-rate (HDR) brachytherapy as monotherapy is an effective treatment option for localized prostate cancer, but experience with single-fraction brachytherapy is limited by studies with small sample size. We report a large single-institution experience with single-fraction HDR brachytherapy as monotherapy for early-stage prostate cancer...

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March 16, 2019

Permanent prostate brachytherapy is safe in men with severe baseline lower urinary tract symptoms

Purpose: To evaluate the long-term urinary outcomes of men with severe pretreatment lower urinary tract symptoms (LUTS) treated with permanent prostate brachytherapy (PPB) ± external beam radiation therapy for localized prostate cancer...

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March 16, 2019

Second breast-conserving surgery and interstitial brachytherapy vs. salvage mastectomy for the treatment of local recurrences: 5-year results

Purpose: The purpose of this study was to report the clinical outcomes of a second breast-conserving therapy (2nd BCT) with perioperative interstitial brachytherapy (iBT) vs. those of salvage mastectomy (sMT) in the treatment of ipsilateral breast tumor recurrences (IBTRs)...

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March 07, 2019

Reducing seed migration to near zero with stranded-seed implants: Comparison of seed migration rates to the chest in 1000 permanent prostate brachytherapy patients undergoing implants with loose or stranded seeds

Purpose: Pulmonary seed emboli to the chest may occur after permanent prostate brachytherapy (PPB). The purpose of this study is to analyze factors associated with seed migration to the chest in a large series of PPB patients from a single institution undergoing implant with either loose seeds (LS), mixed loose and stranded seeds (MS), or exclusively stranded seeds in an absorbable vicryl suture (VS)...

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March 05, 2019

Intraoperative brachytherapy for resected brain metastases

Brain metastases, the most common intracranial neoplasms in adults (1), develop in approximately 30% of all cancer patients, and is the cause of death in up to 50% of these individuals (2). They are commonly located at the gray–white matter interface where the blood vessel caliber decreases, and their dissemination corresponds with blood flow...

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February 28, 2019

Current state of interventional radiotherapy (brachytherapy) education in Italy: results of the INTERACTS survey

Purpose: Rapid evolution and improvement of technology in radiation oncology and the complexity of each area of radiotherapy (RT) practice determined the need for an adequate and flexible practical training system. In the field of interventional radiotherapy (brachytherapy – BT), a decline in BT utilization was detected in the 1990’s, essentially due to technological improvement of external beam RT...

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February 14, 2019

High Dose Rate Brachytherapy versus Low Dose Rate Brachytherapy for the Treatment of Prostate Cancer: A Review of Clinical Effectiveness and Cost-Effectiveness

Prostate cancer is the most common cancer in Canadian adults with prostates and the fourth most common cancer across all Canadians.1 In 2017, there were an estimated 21,300 new cases of prostate cancer diagnosed in Canada and there were an estimated 4,100 deaths...

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February 13, 2019

Personalized re-treatment strategy for uveal melanoma local recurrences after interventional radiotherapy (brachytherapy): single institution experience and systematic literature review

Purpose: Episcleral plaque radiotherapy is an effective method of controlling uveal melanoma locally as confirmed by long-term results [1]. Unfortunately, failure of the radioactive plaque to control tumor growth is occasionally observed [2]. Data published in a review by Chang presents local failure rates following various forms of conservative treatments for uveal melanoma [3]...

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February 07, 2019

Factors associated with deformation accuracy and modes of failure for MRI-optimized cervical brachytherapy using deformable image registration

Purpose: To identify factors associated with MRI-to-CT image deformation accuracy and modes of failure for MRI-optimized intracavitary high-dose-rate treatment of locally advanced cervical cancer...

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February 02, 2019

Understanding the underutilization of cervical brachytherapy for locally advanced cervical cancer

Purpose: To understand the reasons behind current low utilization of brachytherapy for locally advanced cervical cancer in the United States...

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February 01, 2019

Combined-modality 125J-seed-brachytherapy, external beam radiation and androgen deprivation therapy of unfavorable-risk prostate cancer: report of outcomes and side-effects

Purpose: To analyze outcomes and complication rates in an unselected cohort of men with unfavorable (NCCN intermediate and high-risk) PCa receiving combined-modality radiation treatment (CRT)...

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January 18, 2019

Brachytherapy: A critical component of primary radiation therapy for cervical cancer

Brachytherapy is well-established as an integral component in the standard of care for treatment of patients receiving primary radiotherapy for cervical cancer. A decline in brachytherapy has been associated with negative impacts on survival in the era of modern EBRT techniques...

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January 16, 2019

Impact of a dominant intraprostatic lesion (DIL) boost defined by sextant biopsy in permanent I-125 prostate implants on biochemical disease free survival (bDFS) and toxicity outcomes

Background and purpose: To compare bDFS and toxicity outcomes in a population of intermediate risk prostate cancer patients treated using I-125 LDR brachytherapy with or without DIL boost based on multiple core biopsy maps...

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January 10, 2019

Surgery Versus Radiation for High-risk Prostate Cancer: The Fight Continues. But Is It Time To Call a Draw and Reach Consensus?

Management of high-risk prostate cancer (PC) is one of the most contentious issues that urologists face. Level 1 evidence shows that adding external beam radiotherapy (EBRT) to androgen deprivation therapy (ADT) improves survival outcomes in high-risk and locally advanced PC [1]...

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January 09, 2019

Long-term oncological and functional outcomes support use of low-dose-rate brachytherapy with or without external beam radiation in young men (≤60 years) with localized prostate cancer

PURPOSE: To evaluate the oncological and functional outcomes of young men treated with low-dose-rate brachytherapy (BT) for prostate cancer (PCa)...

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January 09, 2019

A comparative analysis of overall survival between high-dose-rate and low-dose-rate brachytherapy boosts for unfavorable-risk prostate cancer

Purpose: External beam radiation therapy (EBRT) with low-dose-rate (LDR) brachytherapy boost has been associated with improved biochemical progression–free survival and overall survival (OS) compared with dose-escalated EBRT (DE-EBRT) alone for unfavorable-risk prostate cancer...

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GEC-ESTRO Brachytherapy Guidelines:

www.estro.org

 

ABS Brachytherapy Guidelines and Consensus Statements:

www.americanbrachytherapy.org